Polyhexamethylene-guanidine hydrochloride solution is a colorless or light yellow transparent liquid, in which guanidine group has high activity, which can make the polymer positive, and is easily adsorbed by all kinds of negative bacteria and viruses, thus inhibiting the division ability of bacteria and viruses and causing them to lose their reproductive ability. In addition, the film formed by the polymer blocks the respiratory channel of microorganisms. Causing the microbes to die quickly.
intro
The average molecular weight of polyhexamethylene biguanide hydrochloride is 1100 ~ 1800, the molecular formula is (C8H17N5)n·xHCl, n=12-16. Polyhexamethylene-biguanide hydrochloride (PHMB) is a broad-spectrum antibiotic that can kill gram-positive bacteria, gram-negative bacteria, fungi and yeasts.
Characteristics Polyhexamethylene biguanide hydrochloride (PHMB) has excellent bactericidal properties, little irritation, low toxicity, low concentration and fast bactericidal speed.
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Polyhexamethylene-biguanide hydrochloride PHMB has been widely used in medicine for sterilization and preservative. As a medical product, it is used to sterilize contact lenses, eye drops, and surgical procedures. Due to the strong tolerance of the eye to PHMB, it can be used as a treatment of acanthamoeba keratitis, prevention and treatment of other eye diseases, and PHMB is also widely used in cosmetics, personal care products, textiles, food industry and so on. With the development of science and technology, polyhexamethylene-chemicalbook guanidine hydrochloride has many new applications. For example, it is used as a flocculant, as a bactericide in swimming pools and industrial water treatment, as a bactericide in oil recovery water injection, and can clean and remove harmful substances from glassware and other hard surfaces.
Antibacterial mechanism
Polyhmethylene biguanide hydrochloride PHMB is a cell membrane active antibacterial agent, and its inhibitory effect on bacterial activity is higher than that of fungi. Its antibacterial mechanism is roughly as follows: First, PHMB is a polycationic compound, which adsorbs on the surface of negatively charged microorganisms and prevents them from dividing and propagating; At the same time, the PHMB adsorbed on the microbial surface acts on the phospholipid bilayer in the cytoplasm through transmembrane transport, and binds to the negatively charged phosphoric acid group, thus changing the selective permeability of the cell membrane, destroying cell metabolism, and killing microorganisms.
Toxicity
Polyhexamethylene-guanidine hydrochloride (PHMB) and polyoxolefin guanidine hydrochloride disinfectant, oral LD50>5000mg/kg for male and female mice, belong to the actual non-toxic grade; The mean score of skin irritation response to rabbits was 0, indicating no irritation in practice. There was no micronucleogenic effect on polychromatic erythrocytes in mouse bone marrow. The cumulative toxicity test showed weak cumulative toxicity. No genotoxicity was shown in mouse germ cells.
use
Disinfection and fungicide. This fungicide is a broad spectrum antibacterial, gram-positive bacteria, gram-negative bacteria, fungi and yeast are capable of killing; Can be used as a fungicide, often used in swimming pool fungicide, universal cleaning agent and disinfectant products.
ABOUT US
Wisdom Drugs Co .,Ltd was founded in Sep. 2011 whose headquarter located in Changzhou Creative Industry Park, having a branch in India. The company’s R&D center is engaged in not only the process development of APIs, intermediates, poly-peptide compounds and heterocyclic compounds,but also the optimization and production. We are devoted to the synthesis customization and the technology transfer, enabling compounds to be scaled from laboratory to commercial to meet the requirements of different customers.
