As an important chemical product and raw material for chemical synthesis of drugs, pharmaceutical intermediates have greater production value and are an important part of fine chemical industry. The replacement of pharmaceutical intermediates is relatively large, and the development direction of Chinese pharmaceutical intermediates is mainly the research and development of new pharmaceutical intermediates or the use of new production processes, and the ability of independent research and development and innovation of enterprises is enhanced. In recent years, the production technology of pharmaceutical intermediates in the world has been greatly developed, among which new technologies such as combinatorial chemistry, biocatalyzation, cellular biochemistry, chiral chemistry, peptide synthesis, carbohydrate synthesis, etc., make the production efficiency of intermediates higher and more friendly to the environment.
1, common pharmaceutical intermediates research and development types:
Vitamin intermediates;
For example, sorbitol used for the production of vitamin C, isophytol of vitamin E and B-ionone, an important intermediate used for the synthesis of vitamin E and vitamin A, have a large market demand and broad prospects.
Heterocyclic compound;
As of the the typical pharmaceutical intermediates.It is widely used in medicine, pesticides and veterinary drugs and intermediates, most of which are maternal (nuclear). For example, cosoya (Losartan potassium tablets) and looxy (amlodipine) for the treatment of hypertension are heterocyclic compounds; The main heterocyclic compounds are imidazole, thiazole, triazole, pyridine, pyrimidine, piperazine and triazine and some of their derivatives.
| fluorinated compounds;
Introduction of new elements into pharmaceutical intermediates to improve, the most successful application being fluorine. At present, there are hundreds of fluorine-containing drugs at home and abroad, and many drugs have become the main varieties for the treatment of some diseases. Fluorine-containing drugs have the characteristics of small dosage, low toxicity, high efficacy and strong metabolic capacity, and have an important position in the pharmaceutical field.
| chiral compounds;
A compound obtained by asymmetric synthesis or resolution on the basis of stereochemistry. Chiral compounds have a wide range of uses and are a very important class of organic compounds. With the development of biotechnology, people will use microbial pathways to develop new chiral products to separate special enzymes and microbial strains, which can be used to produce various chiral amines, chiral amino acids and other chiral intermediates. In order to shorten the new drug research and development cycle, reduce the cost of new drug research and development, and improve the capital turnover rate, intermediates are generally outsourced customized production. Medisi provides chemical technology services, with extensive experience in process optimization of intermediates and apis, development of new, safe and environmentally friendly process routes, and is committed to developing stable, low-cost and large-scale processes for customers.it is really popullar pharmaceutical intermediate.
| biological compounds, etc.
The application of DNA recombination technology, cell engineering technology and enzyme engineering technology to research the treatment of cardiovascular diseases, diabetes, hepatitis, tumor, anti-aging and other medicines, and the application of modern biotechnology to transform the traditional pharmaceutical industry.
About Wisdom Drugs
Wisdom Drugs Co .,Ltd was founded in Sep. 2011 whose headquarter located in Changzhou Creative Industry Park, having a branch in India. The company’s R&D center is engaged in not only the process development of APIs,pharmaceutical intermediates, poly-peptide compounds and heterocyclic compounds,but also the optimization and production. We are devoted to the synthesis customization and the technology transfer, enabling compounds to be scaled from laboratory to commercial to meet the requirements of different customers.
