Background and Overview
Calcium glycerophosphate is widely used in medicine, food, toothpaste and other industries. Its use in food can play the role of calcium supplement; In medicine, it plays the biological and physiological role of calcium, has the function of improving tissue cells, constituting bone tissue, and plays the metabolic role of calcium glycerophosphate, which has the role of supplementing brain vitality. As early as 1960, it was found that calcium glycerophosphate has the effect of antibacterial and anti-caries. It is found that it can increase the content of calcium and phosphorus in tooth enamel, inhibit the demineralization of tooth enamel, and improve the remineralization of tooth enamel. Calcium glycerophosphate can change the acid-alkalinity of tooth enamel surface and enhance its acid-resistant ability. The advantages of calcium glycerophosphate are self-evident, but at present in China’s oral care products industry application is not much, calcium glycerophosphate is an excellent oral additives, especially suitable for calcium supplement toothpaste, chewing gum, but also the ideal raw material of anti-caries additives, can be used in children’s toothpaste to promote the growth of teeth and calcium strengthening. Through the formula experiment of various products, the addition of calcium glycerophosphate, pay attention to the characteristics of calcium glycerophosphate, the stability of most oral care products and other quality indicators are not significantly different from no addition, and can give full play to the ability of calcium glycerophosphate to prevent caries, acid and remineralization of teeth, so greater efforts should be made in this field.
【 Physical and Chemical properties 】
Calcium glycerophosphate is a white crystalline powder. Odorless, almost odorless, slightly bitter, moisture-absorbing. At 130℃, the crystal water is lost to form nothing, and it decomposes above 170℃. 25℃ dissolves in about 50mL of water per gram. At low temperature, it is more soluble in water, and the aqueous solution is alkaline. Citric acid or lactic acid can improve its solubility in water. Almost insoluble in boiling water. Insoluble in ethanol. Calcium glycerophosphate is an isomer with the formula:
Used in medicine to promote calcification and formation of bones and teeth. Food nutrition supplement, food calcium fortifying agent, stabilizer. Toothpaste grade calcium glycerophosphates is used as a toothpaste additive in the toothpaste industry because of its good clarification, high solubility and fast dissolution rate. Calcium glycerophosphate has antibacterial and anti-caries effect. It can increase the content of calcium and phosphorus in tooth enamel, inhibit the demineralization of tooth enamel, and improve the remineralization of tooth enamel. It can change the acid-alkalinity of tooth enamel surface and enhance its acid-resistant ability. Calcium glycerophosphate used as a toothpaste additive has a pH of 1.7ml/g at a certain concentration, and in order not to affect the quality of the toothpaste paste, the clarification of calcium phosphate needs to meet at most a slight turbidity. Calcium hydroxide and glycerophosphate were neutralized and extracted by ethanol to obtain the toothpaste grade calcium glycerophosphate with 1.7ml/g, 80% calcium glycerophosphate content and clarification degree.
The role of calcium glycerophosphate in toothpaste is mainly manifested in the following aspects: ① The control effect on plaque. ② Protective effect on dentin. ③ Influence on the ecological balance of oral flora. In addition, calcium glycerophosphate can improve the absorption of fluoride. Adding 0.1% ~ 0.13% calcium glycerophosphate to toothpaste containing SMFP greatly improves the absorption rate of fluoride and strengthens the anti-demineralization fluorination effect of enamel.
Calcium glycerophosphate is an ideal toothpaste additive for preventing dental caries, treating gingivitis and periodontal disease. Because of the good protective effect of calcium glycerophosphate in toothpaste, it has been favored by the majority of toothpaste manufacturers. Foreign countries, such as Unilever, have the production of calcium glycerophosphate toothpaste, the new rise of domestic national brands such as Nais, Okili, etc., have been optimistic about the market market of high value-added toothpaste of calcium glycerophosphate, and there are small-scale production of calcium glycerophosphate toothpaste. According to the survey, the United States, Japan, Europe, Asia Pacific and other markets pay more attention to high-tech, high-addition toothpaste products, more concerned about the active ingredients in toothpaste. All these indicate that the calcium glycerophosphate toothpaste market has a broad growth space. In addition, calcium glycerophosphate can be used in mouthwashes.
【 Synthesis 】
At present, the main methods for preparing calcium glycerophosphate are phosphoric acid method, phosphorus salt method, phosphorus oxychloride method, oil slag method and so on. The process of these methods is complicated, and the purification process of the target product calcium glycerophosphate is complicated and difficult to control. The method of neutralization of calcium hydroxide and glycerophosphate was used to obtain calcium glycerophosphate by ethanol extraction, which avoided the purification process of calcium glycerophosphate. The reaction equation is as follows
About Wisdom Drugs
Wisdom Drugs Co .,Ltd was founded in Sep. 2011 whose headquarter located in Changzhou Creative Industry Park, having a branch in India. The company’s R&D center is engaged in not only the process development of APIs, intermediates, poly-peptide compounds and heterocyclic compounds,but also the optimization and production. We are devoted to the synthesis customization and the technology transfer, enabling compounds to be scaled from laboratory to commercial to meet the requirements of different customers.
