【 Properties 】 This product is white or light gray crystalline powder.
【 Pharmacology 】 Albinone is a relatively new broad-spectrum anticoccidial drug. It has the advantages of small dosage and no cross resistance. It has obvious inhibitory effect on spore, 1st and 2nd generation schizozoites, so that the early lesions do not continue to develop, and the intestinal tract can maintain normal absorption function, thus playing a good role in animal weight gain. The mechanism of anticoccidia action of albinone is still unclear.
[Use] Albione has a suppressive effect on a variety of coccidia, especially sensitive to chicken tender, toxic, giant Eimeria, and even 1-medicine. All online www.med126.com2mg/kg feed concentration has good effect. The recommended concentration of 3mg/kg must be used to prevent the excretion of oocystis for the compost type, Eimeria brucei, and Eimeria minor of Turkey, Eimeria glandulata, and Eimeria peacock. It is still effective against coccidia resistant to chloropyridine and quinolines. In foreign countries, algonone is also used for bovine Taylorworm infection as well as sheep and goats.
The addition of 3mg/kg in the feed has a good killing effect on tender, toxic, pile type, giant and Eimeria bruci of chickens, and there is no recurrence after withdrawal of the drug, indicating that this insecticidal effect is irreversible. It can exert insecticidal effect in the sporozoite stage and the first and second generation schizozoite stage of coccidia development. At the same time, it has also been verified that albinone can promote the growth of broilers, improve feed efficiency and reduce mortality.
In the mid-1980s, studies have shown that alsinone can specifically inhibit the synthesis of fiber cells type collagen fiber, is a new type of collagen synthesis inhibition, can prevent liver fibrosis, pulmonary fibrosis, scleroderma and other diseases characterized by excessive collagen synthesis, wound healing and scar formation also have an inhibitory effect.
Recently, it has also been found that the performance of olsinone is particularly outstanding in preclinical studies of anti-tumor, and it has significant inhibitory effect on many cancer models such as liver cancer, sarcoma, brain cancer, bladder cancer, breast cancer and prostate cancer.
[Note] (1) The safe range of almonone is narrow, and the therapeutic concentration (3mg/kg) is safe for chickens, turkeys, rabbits, etc., but it can inhibit the growth rate of waterfowl (geese, ducks). Guinea fowl are the most sensitive and easily poisoned to death. As fish and aquatic organisms are very sensitive to this product, do not contaminate water sources by feeding chicken manure and containers. (2) It has recently been confirmed that albilone has an inhibitory effect on the synthesis of type I collagen cells in poultry and mammals, resulting in Skin tears in treated poultry. The treatment concentration can affect the weight gain rate of healthy chicks, accelerate blood clotting, and affect the immunity of turkeys to coccidia. (3)6mg/kg feed concentration will affect the palatability, so that sick chickens eat less (medicine), 9mg/kg most chickens refuse to eat. Therefore, the drug must be fully mixed, and the uniformity is required to be between 2.1-3.9mg/kg, otherwise the efficacy will be affected. (4) Due to continuous application, most chicken farms in China have serious coccidia drug resistance. (5) It is prohibited to use with other anticoccidial drugs. (6) Turkey over 12 weeks of age, pheasant over 8 weeks of age, laying hens and waterfowl are prohibited. (7) Drug withdrawal period, broiler 5 days, Turkey 7 days.
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