Classification and application of pharmaceutical intermediates: in-depth interpretation
In the pharmaceutical industry, pharmaceutical intermediates play a very important role. They are key ingredients in the manufacture of drugs and can be further transformed into final pharmaceutical products. Therefore, it is essential to have a comprehensive understanding of the classification and application of pharmaceutical intermediates.
1. Organic synthesis is the main method of preparing pharmaceutical intermediates. According to the type of reaction and the desired structure, pharmaceutical intermediates can be divided into the following categories:
(1) Alcohol intermediates: These intermediates are usually prepared by oxidation or reduction reactions of alcohols. They are widely used in pharmaceutical processes for the preparation of esters, ethers and amines.
(2) Ketone intermediates: ketone intermediates can be prepared by the REDOX reaction of carbonyl compounds. They are important in the process of synthesizing drugs and can be used in the construction of generative rings as well as the introduction of other organic functional groups.
(3) Acid intermediates: acid intermediates are usually prepared by the esterification of carboxylic acids or the reduction of carboxylic acids. They play a vital role in drug synthesis and are widely used in acylation reaction, esterification reaction, peptide synthesis and so on.
(4) olefin intermediates: These intermediates are usually prepared by the synthesis of olefin. They play an important role in the structural modification and ring construction of drugs.
2. According to the application field of pharmaceutical intermediates, they can be further classified into the following categories:
(1) Antibiotic intermediates: Antibiotics are drugs used to treat various bacterial infections. The preparation of antibiotic intermediates is a key step in the synthesis of various antibiotics, including β-lactam, aminoglycoside, tetracycline, etc.
(2) Anti-tumor intermediates: The research and development of anti-tumor intermediates is the prerequisite for the preparation of anti-tumor drugs. By synthesizing and optimizing these intermediates, more effective and less toxic anti-tumor drugs, such as DNA acidifiers and cell cycle inhibitors, can be obtained.
Cardiovascular intermediates: Cardiovascular disease is a major health threat around the world. The synthesis of cardiovascular intermediates is a key step in the preparation of antihypertensive, lipid-regulating and cardiological drugs.
(4) Antiviral intermediates: Today, the world is facing the challenge of many viral diseases. Research into the synthesis of antiviral intermediates is essential for the preparation of antiviral drugs, including drugs against HIV, influenza A viruses and hepatitis B viruses.
In-depth research on the classification and application of pharmaceutical intermediates will help promote the development and manufacture of new drugs. The synthesis and optimization of these intermediates will create more opportunities for the pharmaceutical industry and bring benefits to human health.
ABOUT US
Wisdom Drugs Co .,Ltd was founded in Sep. 2011 whose headquarter located in Changzhou Creative Industry Park, having a branch in India. The company’s R&D center is engaged in not only the process development of APIs, intermediates, poly-peptide compounds and heterocyclic compounds,but also the optimization and production. We are devoted to the synthesis customization and the technology transfer, enabling compounds to be scaled from laboratory to commercial to meet the requirements of different customers.
