| Melting point: | 120-122 °C(lit.) |
| Boiling point: | 257.0±20.0 °C(Predicted) |
| Density: | 1.3486 (estimate) |
| Storage conditions: | Sealed in dry,Room Temperature |
| Solubility: | Chloroform (Slightly), Methanol (Slightly) |
| Acidity factor (pKa): | 3.80±0.10(Predicted) |
| Form: | Solid |
| Color: | white |
Application
3, 4-difluorobenzoic acid is a substituted benzoic acid compound. Substituted benzoates are a kind of organic synthetic intermediates which can be mainly developed, which can be used in the production of organic chemical raw materials and a variety of pesticides, and also the synthetic intermediates of dyes, pesticides and medicines. It is a raw material for preservatives and spices, and can also be used for liquid crystal materials, with high value and good market prospects.
Preparation
Wittig reagent 3, 4-difluorophenylmethyltriphenylphosphine 416mg(1mmol) was added into a 100ml round bottom flask of dried chemical bookmL, followed by 30ml of THF and 1ml(9mmol) 30% hydrogen peroxide solution, and the reaction was carried out under the protection of nitrogen at 50℃. After 12h, the reaction of raw wittig reagent was almost complete. At the end of the reaction, most of the solvent was removed by rotary steaming, and 10mL of dichloromethane and water were added to extract in separate liquid. The organic phase is dried and concentrated by adding anhydrous sodium sulfate. The crude product was separated into light yellow solid, 134mg, the product was 85%.
An important intermediate for preparing the herbicide cyfluoxate
About Wisdom Drugs
Wisdom Drugs Co .,Ltd was founded in Sep. 2011 whose headquarter located in Changzhou Creative Industry Park, having a branch in India. The company’s R&D center is engaged in not only the process development of APIs, intermediates, poly-peptide compounds and heterocyclic compounds,but also the optimization and production. We are devoted to the synthesis customization and the technology transfer, enabling compounds to be scaled from laboratory to commercial to meet the requirements of different customers.
